Recombinant Anti-CD5 Antibody (PerCP), Rabbit Monoclonal sinobiological 50403-R249-C

$100.00
In stock
SKU
50403-R249-C
Catalog No.SizePrice (USD)
50403-R249-C-2525 Tests$103.68
50403-R249-C-100100 Tests$325.84

General Information

Product nameRecombinant Anti-CD5 Antibody (PerCP), Rabbit Monoclonal
Validated applicationsFCM (FAQ Protocol)
Species reactivityReacts with: Mouse
SpecificityMouse CD5
ImmunogenRecombinant Mouse CD5 protein (Catalog#50403-M08H)
PreparationThis antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD5 (rM CD5; Catalog#50403-M08H; NP_031676.3; Met1-Pro371) and conjugated with PerCP under optimum conditions, the unreacted PerCP was removed.
SourceMonoclonal Rabbit IgG Clone #249
PurificationProtein A
FormulationPBS solution containing 0.5% BSA and 0.09% sodium azide
Concentration5 μl/Test, 0.1 mg/ml
ConjugatePerCP
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Synonyms: Anti-Cd5 Antibody; Anti-Ly-1 Antibody; Anti-Ly-12 Antibody; Anti-Ly-A Antibody; Anti-Lyt-1 Antibody

Image / Experimental Information

Image 1 DescriptionFlow cytometric analysis of mouse CD5 expression on splenocytes.
Image 1 Alt TextHuman CEACAM‑1/CD66a Flow Cytometry (FC) 4964
Image 1 URLSource image

Background Information

Full NameCD5 molecule
DescriptionThe cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD5 is a member of the CD system. CD5 was found to be widely distributed in T-cells and B1 cells which is a subset of IgM-secreting B cells. CD5 also was found expressed in small lymphocytic lymphoma, hairy cell leukaemia and mantle cell lymphoma cells. CD5 serves to weaken the activating stimulus from the BCR so that the B1 cells can only reflect to the very strong stimuli but not the normal tissue proteins.
Research Areas
  • ITIM/ITAM Immunoreceptors and Related Molecules
References
  1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters. 134 (2): 104-12.
  4. Kirchgessner H, et al. (2001) The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J Exp Med. 193 (11): 1269-84.

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