| Catalog No. | Size | Price (USD) |
| 50087-RP01-100 | 100 µL | $147.96 |
| 50087-RP01-200 | 200 µL | $251.64 |
| 50087-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-IL-2R gamma/CD132 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse IL-2R gamma/CD132 |
| Immunogen | Recombinant Mouse CD132 / IL2RG protein (Catalog#50087-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse CD132 / IL2RG (rM CD132 / IL2RG; Catalog#50087-M08H; NP_038591.1; Met 1-Ala 263). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD132 Antibody; Anti-gamma(c) Antibody; Anti-gc Antibody; Anti-Il2rg Antibody; Anti-p64 Antibody; Anti-[g]c Antibody
Background Information
| Full Name | interleukin 2 receptor, gamma |
| Description | The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG), is a cytokine receptor subunit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15, and the interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (X-SCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor based on chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why a deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency. |
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