| Catalog No. | Size | Price (USD) |
| 207319-T02-50 | 50 µL | $147.96 |
| 207319-T02-100 | 100 µL | $251.64 |
| 207319-T02-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-MYCL Antibody, Rabbit Polyclonal |
| Validated applications | ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human MYCL |
| Immunogen | E. coli-derived Human MYCL fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human MYCL fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-bHLHe38 Antibody; Anti-L-Myc Antibody; Anti-LMYC Antibody; Anti-MYCL1 Antibody
Image / Experimental Information
| Image 1 Description | Immunofluorescence staining of MYCL in HeLa cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-Human MYCL polyclonal antibody (dilution ratio 1:100) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Nucleus and Cytoplasm. |
| Image 1 Alt Text | Human MYCL Immunofluorescence(IF) 26455 |
| Image 1 URL | Source image |
Background Information
| Full Name | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog |
| Description | All members of the MYC family are structural partners of MAX, which shares a basic helix-loop-helix (bHLH) domain and confers DNA-binding specificity to the heterodimer. The MYC family genes (MYC, MYCN and MYCL) are among the most deregulated proto-oncogenes in human cancer. Aberrant MYC expression is frequently associated with poor prognosis. MYCL (L-Myc) is frequently amplified in human small cell lung cancer (SCLC). MYCL is required by a Batf3-dependent classical dendritic cell subset (cDC1) for optimal CD8 T cell priming. MYCL is highly dynamic and might rather be a surrogate marker for disturbed energy metabolism than the underlying cause of cardiac dysfunction. |
| References |
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