Human Endoglin/CD105 ELISA Kit sinobiological KIT10149
$400.00
In stock
SKU
KIT10149
| Catalog No. | Size | Price (USD) |
| KIT10149-1 | 1 Kit (96 Tests) | $414.71 |
General Information
| Product name | Human Endoglin/CD105 ELISA Kit |
| Specificity | This assay recognizes both recombinant and natural Human CD105. |
| Conjugate | HRP |
| Shipping | This ELISA Kit is shipped at ambient temperature. |
| Storage | Unopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA |
| Assay type | Solid Phase Sandwich ELISA (quantitative) |
| Sample type | Serum |
| Sensitivity | 15.5 pg/mL |
| Assay range | 93.75-6000 pg/mL |
| Materials provided | 1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution |
| Product overview | This Human Endoglin/CD105 ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Human Endoglin/CD105 protein in Serum . It contains recombinant Human Endoglin/CD105, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use. |
Synonyms: CD105 ELISA Kit, Human; END ELISA Kit, Human; HHT1 ELISA Kit, Human; ORW1 ELISA Kit, Human
Image / Experimental Information
| Image 1 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 1 Alt Text | Human Endoglin/CD105 ELISA Kit Standard Curve 39 |
| Image 1 URL | Source image |
| Image 2 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 2 Alt Text | Human Endoglin/CD105 ELISA Kit Specificity 249 |
| Image 2 URL | Source image |
Background Information
| Full Name | endoglin |
| Description | Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type II receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types. |
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