Human HE4/WFDC2 ELISA Kit sinobiological KIT12609

$400.00
In stock
SKU
KIT12609
Catalog No.SizePrice (USD)
KIT12609-11 Kit (96 Tests)$414.71

General Information

Product nameHuman HE4/WFDC2 ELISA Kit
SpecificityRecognizes both recombinant and natural Human HE4/WFDC2/WAP5
ConjugateHRP
ShippingThis ELISA Kit is shipped at ambient temperature.
StorageUnopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA
Assay typeSolid Phase Sandwich ELISA (quantitative)
Sample typeSerum
Sensitivity6.57 pg/mL
Assay range31.25-2000 pg/mL
Materials provided1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution
Product overviewThis Human HE4/WFDC2 ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Human HE4/WFDC2 protein in Serum . It contains recombinant Human HE4/WFDC2, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.

Synonyms: dJ461P17.6 ELISA Kit, Human; EDDM4 ELISA Kit, Human; HE4 ELISA Kit, Human; WAP5 ELISA Kit, Human

Image / Experimental Information

Image 1 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 1 Alt TextHuman HE4/WFDC2/WAP5 ELISA Kit Standard Curve 17918
Image 1 URLSource image

Background Information

Full NameWAP four-disulfide core domain 2
DescriptionWAP four-disulfide core domain protein 2, also known as Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2 and HE4, is a secreted protein that contains two WAP domains. WFDC2 / HE4 is a member of a family of stable 4-disulfide core proteins that are secreted at high levels. It is expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. It is highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. WFDC2 may be a component of the innate immune defences of the lung, nasal and oral cavities and suggest that WFDC2 functions in concert with related WAP domain containing proteins in epithelial host defence. WFDC2 re-expression in lung carcinomas may prove to be associated with tumour type and should be studied in further detail. Mammary gland expression of tammar WFDC2 during the course of lactation showed WFDC2 was elevated during pregnancy, reduced in early lactation and absent in mid-late lactation. WFDC2 / HE4 can undergo a complex series of alternative splicing events that can potentially yield five distinct WAP domain containing protein isoforms.
Research Areas
  • Serine Proteases and Regulators
References
  1. Bingle,L. et al., 2002, Oncogene. 21 (17):2768-73.
  2. Hellström,I. et al., 2003, Cancer Res. 63 (13):3695-700.
  3. Bingle,L. et al., 2006, Respir Res. 7 : 61.
  4. Galgano,M.T. et al., 2006, Mod Pathol.19 (6):847-53.
  5. Sharp,J.A. et al., 2007, Evol Dev. 9 (4): 378-92.

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