Human P-Selectin/CD62P ELISA Kit sinobiological KIT13025

$400.00
In stock
SKU
KIT13025
Catalog No.SizePrice (USD)
KIT13025-11 Kit (96 Tests)$414.71

General Information

Product nameHuman P-Selectin/CD62P ELISA Kit
SpecificityThis assay recognizes both recombinant and natural Human SELP.
ConjugateHRP
ShippingThis ELISA Kit is shipped at ambient temperature.
StorageUnopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA
Assay typeSolid Phase Sandwich ELISA (quantitative)
Sample typeSerum
Sensitivity10.91 pg/mL
Assay range50-3200 pg/mL
Materials provided1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution
Product overviewThis Human P-Selectin/CD62P ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Human P-Selectin/CD62P protein in Serum . It contains recombinant Human P-Selectin/CD62P, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.

Synonyms: CD62 ELISA Kit, Human; CD62P ELISA Kit, Human; GMP140 ELISA Kit, Human; GMRP ELISA Kit, Human; GRMP ELISA Kit, Human; LECAM3 ELISA Kit, Human; PADGEM ELISA Kit, Human; PSEL ELISA Kit, Human

Image / Experimental Information

Image 1 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 1 Alt TextHuman P-Selectin/CD62P/SELP ELISA Kit Standard Curve 116
Image 1 URLSource image
Image 2 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 2 Alt TextHuman P-Selectin/CD62P/SELP ELISA Kit Specificity 200
Image 2 URLSource image

Background Information

Full Nameselectin P (granule membrane protein 140kDa, antigen CD62)
DescriptionP selectin (SELP) is a 140kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. SELP mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. P selectin is a cell adhesion molecule on the surface of activated endothelial cells. Cellular adhesion molecules are a large family of proteins that attach the cytoskeleton and intracellular signaling cascades with the extracellular environment. SELP is a calcium-dependent receptor for myeloid cells that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes.
References
  1. Johnson-Tidey RR, et al. (1994) Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques. Coexpression with intercellular adhesion molecule-1. Am J Pathol. 144(5):952-61.
  2. Walcheck B, et al. (1996) Neutrophil-neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-1. A mechanism that amplifies initial leukocyte accumulation of P-selectin in vitro. J Clin Invest. 98(5):1081-7.
  3. Foreman KE, et al. (1994) C5a-induced expression of P-selectin in endothelial cells. J Clin Invest. 94(3):1147-55.

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