Human TREM-2 ELISA Kit sinobiological KIT11084
$714.00
In stock
SKU
KIT11084
| Catalog No. | Size | Price (USD) |
| KIT11084-1 | 1 KIT (96 Tests) | $740.55 |
General Information
| Product name | Human TREM-2 ELISA Kit |
| Specificity | This assay recognizes recombinant Human TREM2. |
| Conjugate | HRP |
| Shipping | This ELISA Kit is shipped at ambient temperature. |
| Storage | Unopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA |
| Assay type | Solid Phase Sandwich ELISA (quantitative) |
| Sample type | Recombinant protein |
| Sensitivity | 33.48 pg/mL |
| Assay range | 78.13-5000 pg/mL |
| Materials provided | 1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution |
| Product overview | This Human TREM-2 ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Human TREM-2 protein in Recombinant protein . It contains recombinant Human TREM-2, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use. |
| Interference | Preparations of human TREML2 at 50 ng/mL in a mid-range recombinant human TREM2 control were assayed for interference. No significant interference was observed. |
Synonyms: PLOSL2 ELISA Kit, Human; TREM-2 ELISA Kit, Human; Trem2a ELISA Kit, Human; Trem2b ELISA Kit, Human; Trem2c ELISA Kit, Human
Image / Experimental Information
| Image 1 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 1 Alt Text | Human TREM-2/TREM2 ELISA Kit Standard Curve 17 |
| Image 1 URL | Source image |
| Image 2 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 2 Alt Text | Human TREM-2/TREM2 ELISA Kit Specificity 150 |
| Image 2 URL | Source image |
Background Information
| Full Name | triggering receptor expressed on myeloid cells 2 |
| Description | Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary. |
| References |
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