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Anti-IL-21 Antibody (Biotin), Rabbit Polyclonal sinobiological 10584-T16-B

Anti-IL-21 Antibody (Biotin), Rabbit Polyclonal sinobiological 10584-T16-B

Name: Anti-IL-21 Antibody (Biotin), Rabbit Polyclonal sinobiological 10584-T16-B
SKU: 10584-T16-B
Price: 357 USD
Availability: InStock

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$357.00

In stock

SKU

10584-T16-B

Catalog No.	Size	Price (USD)
10584-T16-B-100	100 µg	$370.28

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Product introduction

General Information

Product name	Anti-IL-21 Antibody (Biotin), Rabbit Polyclonal
Validated applications	ELISA (FAQ Protocol)
Species reactivity	Reacts with: Human
Specificity	Human IL-21
Immunogen	Recombinant Human IL-21 protein (Catalog#10584-HNAE)
Preparation	Produced in rabbits immunized with purified, recombinant Human IL-21 (rh IL-21; Catalog#10584-HNAE; Q9HBE4-1; Gln30-Ser162). IL-21 specific IgG was purified by Human IL-21 affinity chromatography and then biotinylated.
Source	Polyclonal Rabbit IgG
Purification	Protein A & Antigen Affinity
Formulation	0.2 μm filtered solution in PBS
Conjugate	Biotin
Form	Liquid
Shipping	This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-CVID11 Antibody; Anti-IL-21 Antibody; Anti-Za11 Antibody

Background Information

Full Name	interleukin 21
Description	IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as a therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation).
Related Pathways	AKT Signaling Pathway Jak-Stat Signaling Pathway Autophagy Pathway Common G-Chain signaling pathway IL12 signaling pathway
Tags	Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy
References	Coquet JM, et al. (2007) IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol. 178(5):2827-34. Wei L, et al. (2007) IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem. 282(48):34605-10. Parrish-Novak J, et al. (2002) Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol. 72(5):856-63. 4 Kuchen S, et al. (2007) Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. J Immunol. 179(9):5886-96.