| Catalog No. | Size | Price (USD) |
| 310250-T08-50 | 50 µL | $147.96 |
| 310250-T08-100 | 100 µL | $251.64 |
| 310250-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-IL-5R alpha Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human IL-5R alpha |
| Immunogen | E. coli-derived Human IL5RA fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human IL5RA fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD125 Antibody; Anti-CDw125 Antibody; Anti-HSIL5R3 Antibody; Anti-IL5R Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human IL5RA in human stomach with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human IL5RA Immunohistochemistry(IHC) 35183 |
| Image 1 URL | Source image |
Background Information
| Full Name | interleukin 5 receptor, alpha |
| Description | Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA (CD125) is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand-specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony-stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported. IL5RA (CD125) is a T-cell-derived cytokine that is particularly important in the development of asthma for the terminal differentiation, activation, and survival of committed eosinophil precursors. |
| Related Pathways |
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| References |
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