| Catalog No. | Size | Price (USD) |
| 13186-T16-50 | 50 µL | $147.96 |
| 13186-T16-100 | 100 µL | $251.64 |
| 13186-T16-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-MAG/Siglec-4a Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human MAG/Siglec-4a |
| Immunogen | Recombinant Human MAG Protein (Catalog#13186-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human MAG (rh MAG; Catalog#13186-H08H; P20916; Met1-Pro516). MAG specific IgG was purified by Human MAG affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-GMA Antibody; Anti-S-MAG Antibody; Anti-SIGLEC-4A Antibody; Anti-SIGLEC4 Antibody; Anti-SIGLEC4A Antibody; Anti-SPG75 Antibody
Background Information
| Full Name | myelin associated glycoprotein |
| Description | The myelin-associated glycoprotein (MAG) contains five immunoglobulin-like domains and belongs to the sialic-acid-binding subgroup of the Ig superfamily. MAG is a transmembrane glycoprotein of 100kDa localized in myelin sheaths of Periaxonal Schwann cell and oligodendroglial membranes where it functions in glia-axon interactions. It appears to function both as a receptor for an axonal signal that promotes the differentiation, maintenance, and survival of oligodendrocytes and as a ligand for an axonal receptor that is needed for the maintenance of myelinated axons. MAG contains a carbohydrate epitope shared with other glycoconjugates that is a target antigen in autoimmune peripheral neuropathy associated with IgM gammopathy and has been implicated in a dying back oligodendrogliopathy in multiple sclerosis. MAG is considered as a transmembrane protein of both CNS and PNS myelin and it strongly inhibits neurite outgrowth in both developing cerebellar and adult dorsal root ganglion neurons. In contrast, MAG promotes neurite outgrowth from newborn DRG neurons. Thus, MAG may be responsible for the lack of CNS nerve regeneration and may influence both temporally and spatially regeneration in the PNS. |
| References |
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