| Catalog No. | Size | Price (USD) |
| 90841-C08H-50 | 50 µg | $342.14 |
| 90841-C08H-200 | 200 µg | $862.01 |
| 90841-C08H-500 | 500 µg | $2,229.07 |
General Information
| Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Shipping | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
| Stability & Storage | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution | To find reconstitution info, click on 'COA' at the top of the page, enter the lot number and product size for the lot-specific COA. |
| Purity | ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC. |
| Activity | 1.Immobilized LAG3 Protein, Cynomolgus, Recombinant (74 Pro, His Tag)(Cat:90841-C08H) at 2 μg/mL (100 μL/well) can bind FGL1 Protein, Cynomolgus, Recombinant (hFc Tag)(Cat:90926-C02H), the EC 50 is 140-760 ng/mL. 2.Immobilized Recombinant Cynomolgus LAG3/CD223(74 Pro,His Tag) Cat: 90841-C08H) at 2μg/mL (100μL/well) can bind Anti-LAG3(BMS)-IgG4 Antibody, the EC 50 is 60-180 ng/mL. |
| Protein Construction | A DNA sequence encoding the cynomolgus LAG3 (XP_005570011.1) (Met1-Leu450, 74 Pro) was expressed with a polyhistidine tag at the C-terminus. |
| Accession# | XP_005570011.1 |
| Expressed Host | HEK293 Cells |
| Species | Cynomolgus |
| Predicted N Terminal | Val 20 |
| Molecule Mass | The recombinant LAG3 consists of 437 amino acids and predicts a molecular mass of 47.4 kDa. As a result of glycosylation, it migrates as an approximately 57.73 and 132.72 kDa band in SDS-PAGE under reducing conditions. |
Image / Experimental Information
| Image 1 Description | Immobilized LAG3 Protein, Cynomolgus, Recombinant (74 Pro, His Tag)(Cat:90841-C08H) at 2 μg/mL (100 μL/well) can bind FGL1 Protein, Cynomolgus, Recombinant (hFc Tag)(Cat:90926-C02H), the EC 50 is 140-760 ng/mL. |
| Image 1 Alt Text | Cynomolgus LAG3 Protein 34011 |
| Image 1 URL | Source image |
| Image 2 Description | Immobilized LAG3 Protein, Cynomolgus, Recombinant (74 Pro, His Tag)(Cat:90841-C08H) at 2 μg/mL (100 μL/well) can bind FGL1 Protein, Cynomolgus, Recombinant (hFc Tag)(Cat:90926-C02H), the EC 50 is 140-760 ng/mL. |
| Image 2 Alt Text | Cynomolgus LAG3 Protein 36392 |
| Image 2 URL | Source image |
| Image 3 Description | Immobilized LAG3 Protein, Cynomolgus, Recombinant (74 Pro, His Tag)(Cat:90841-C08H) at 2 μg/mL (100 μL/well) can bind FGL1 Protein, Cynomolgus, Recombinant (hFc Tag)(Cat:90926-C02H), the EC 50 is 140-760 ng/mL. |
| Image 3 Alt Text | Cynomolgus LAG3 Protein 37612 |
| Image 3 URL | Source image |
| Image 4 Description | Immobilized LAG3 Protein, Cynomolgus, Recombinant (74 Pro, His Tag)(Cat:90841-C08H) at 2 μg/mL (100 μL/well) can bind FGL1 Protein, Cynomolgus, Recombinant (hFc Tag)(Cat:90926-C02H), the EC 50 is 140-760 ng/mL. |
| Image 4 Alt Text | Cynomolgus LAG3/LAG-3/CD223 Protein 18652 |
| Image 4 URL | Source image |
Background Information
| Full Name | lymphocyte-activation gene 3 |
| Description | LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease. |
| Research Areas |
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| References |
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title: Antibody and bispecific antibody targeting LAG-3 and use thereof
authors: Jiajian Liu
date: 2026-03-31
cited_by_count: 0
techniques: Blocking Assay; Cloning; Expressing; Incubation; Purification; Recombinant; Sequencing
bioz_score: 94
